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. 2020 Jul 23;21(15):5240. doi: 10.3390/ijms21155240

Figure 1.

Figure 1

Olean-12-en-27-oic acid derivatives inhibit RANKL-induced osteoclastogenesis. (A) Chemical structures of olean-12-en-27-oic acid derivatives isolated from A. rossi. (B) Effect of olean-12-en-27-oic acid derivatives on RANKL-induced osteoclastogenesis. RAW264.7 cells were cultured into 96 well-plates under stimulation of RANKL with or without different concentrations of the indicated compound for four days, then the cells were stained for TRAP. The quantities of TRAP-positive multinucleated (> 5 nuclei) osteoclasts were determined following image capture. Data are presented as the mean ± SE (* p < 0.05 and ** p < 0.01, versus vehicle-treated control; n = 3).