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. 2020 Jul 25;21(15):5286. doi: 10.3390/ijms21155286

Table 1.

Proteomic analysis in studies on Idiopathic Pulmonary Fibrosis (IPF).

Study Species Sample Increased Expression
Todd et al. [49] Human Peripheral blood APOA1, complement C1r subcomponent, ICAM5, CC-motif chemokine 18, 14-3-3 SFN, sonic hedgehog protein, Oxidized low density lipoprotein. Receptor 1, MMP3, macrophage capping protein, HSP90β-1.
Foster et al. [50] Human BALF Eosinophil cationic protein, eosinophil lysophospholipase, MMP8, osteopontin, CC-motif chemokine 18 and collagens.
Carleo et al. [51] Human BALF Polymeric immunoglobulin receptors, α-1-B-glycoprotein, fibrinogen-γ, α-1-antitrypsin, complement C3, isocitrate, dehydrogenase, peroxiredoxin 1, ceruloplasmin, serotransferrin, SPA2 and hemopexin.
Ohlmeier et al. [52] Human BALF esRAGE
Tian et al. [53] Human Lung Collagen 1, cathepsin B, AGR-2, galectin-7, HSP90α, HSP90β
Landi et al. [54] Human Lung Alpha-1-antitripsin, SEPRINA3, GSTP1, 14-3-3, HSF-1, NF-AT4, C-Myc
Korfei et al. [55] Human Lung HSP90α, HSP90β, HSP60
Schiller et al. [56] mice Lung Emylin-2, Collagen-XXVIII, Wnt1

Summarized data from different proteomic studies on IPF. APOA1: Apolipoprotein A-1, ICAM-5: intracellular adhesion molecule 5; SFN 14-3-3 protein Sigma; MMP3: Matrix MetalloProteinase 3; HSP90β-1: Heat Shock Protein 90β-1; MMP8: Matrix MetalloProteinase 8; SPA2: Surfactant Associated Protein A2; esRAGE: endogenous soluble form of Receptor for Advanced Glycation End-products; AGR-2: Anterior Gradient Protein 2; HSP90α: Heat Shock Protein α; SEPRINA3: alpha-1-antychymotripsin; GSTP1: Glutathione S Transferase P1; HSF-1: Heat Shock Factor 1; NF-AT4: Nuclear Factor of Activated T cell.