ADM	Acinar-to-ductal metaplasia
apCAFs	Antigen-presenting CAFs
APCs	Antigen presenting cells
α-SMA	alpha-Smooth muscle actin
α-SMA-tk	alpha-Smooth muscle actin-thymidine kinase
CA-MSCs	Cancer-associated mesenchymal stem cells
CAFs	Cancer-associated fibroblasts
Cre	Cre recombinase
CTLA-4	Cytotoxic T-lymphocyte-associated protein 4
BMSCs	Bone marrow-derived mesenchymal stem cells
CCL2	C-C motif ligand 2
CDKN2A	Cyclin-dependent kinase inhibitor 2A
CXCL1	C-X-C motif chemokine ligand 1
CXCL2	C-X-C motif chemokine ligand 2
CXCL8	C-X-C motif chemokine ligand 8
CXCL12	C-X-C motif chemokine ligand 12
CXCR4	C-X-C chemokine receptor 4
DC	Dendritic cells
DRG	Dorsal root ganglia
ECM	Extracellular matrix
EndMT	Endothelial-to-mesenchymal transition
EMT	Epithelial-to-mesenchymal transition
FAK	Focal adhesion kinase
FAP	Fibroblast activation protein
FoxP3	Forkhead box P3
FSP1	Fibroblast-specific protein 1
GAS6	Growth arrest-specific gene 6
GM-CSF	Granulocytic-macrophage colony-stimulating factor
HGF	Hepatocyte growth factor
HH	Hedgehog
HIF-1α	Hypoxia-inducible factor 1-alpha
iCAFs	inflammatory CAFs
IFN-γ	Interferon-gamma
IGF1	Insulin-like growth factor 1
IGF1R	Insulin-like growth factor 1 receptor
IHC	Immunohistochemistry
IL-1	Interleukin-1
IL-1R	Interleukin-1 receptor
IL-6	Interleukin-6
IL-11	Interleukin-11
IL-33	Interleukin-33
JAK	Janus kinase
KC	Pdx1-Cre;LSL-KrasG12D/+
KPC	Pdx1-Cre;LSL-KrasG12D/+;LSL-p53R172H
KPCY	Pdx1-Cre;LSL-KrasG12D/+;p53flox/+;LSL-Rosa26YFP/+
KPflC	Pdx1-Cre;LSL-KrasG12D/+;p53flox/+
KPP	Pdx1-Cre;LSL-KrasG12D/+;p16/p19flox/flox
KRAS	Kirsten rat sarcoma virus
LCK	Lymphocyte-specific protein tyrosine kinase
LGD IPMN	Low-grade intraductal papillary mucinous neoplasm
HGD IPMN	High-grade intraductal papillary mucinous neoplasm
LIF	Leukemia inhibitory factor
LIFR	Leukemia inhibitory factor receptor
LPC	Lysophosphatidylcholine
LRRC15	Leucine-rich repeat containing 15
MAPK	Mitogen-activated protein kinase
MCP-1	Monocyte chemoattractant protein-1
M-CSF	Macrophage-colony stimulating factor
MCT1	Monocarboxylate transporter 1
MCT4	Monocarboxylate transporter 4
MDSCs	Myeloid-derived suppressor cells
MHC	Major histocompatibility complex
miRNA	microRNA
MMP9	Matrix metallopeptidase 9
MSCs	Mesenchymal stem cells
myCAFs	myofibroblastic CAFs
NF-κB	Nuclear factor kappa-light-chain-enhancer of activated B cells
NGF	Nerve growth factor
NI	Neural invasion
NK cells	Natural killer cells
OTI	MHC class I-restricted ovalbumin-specific T cell receptor
OTII	MHC class II-restricted ovalbumin-specific T cell receptor
OVA	Ovalbumin
PanIN	Pancreatic intraepithelial neoplasia
PBMCs	Peripheral blood mononuclear cells
PD-1	Programmed death-1
PD-L1	Programmed death-ligand 1
PDAC	Pancreatic ductal adenocarcinoma
PDGF	Platelet-derived growth factor
PDGFRα	Platelet-derived growth factor receptor-alpha
PDGFRβ	Platelet-derived growth factor receptor-beta
PDPN	Podoplanin
Pdx1	Pancreatic and duodenal homeobox 1
PKT	Ptf1a-Cre;LSL-KrasG12D/+;Tgfbr2flox/flox
PODXL	Podocalyxin
PSCs	Pancreatic stellate cells
PTCH	Patched
PTF1α	Pancreas associated transcription factor 1-alpha
RCP	Rab-coupling protein
ROS	Reactive oxygen species
SAA3	Serum amyloid A3
scRNA-seq	Single cell RNA-sequencing
SHH	Sonic hedgehog
SMAD4	Mothers against decapentaplegic homolog 4
SMO	Smoothened
SOCS1	Suppressor of cytokine signaling 1
ST2	Suppression of tumorigenicity 2
STAT3	Signal transducer and activator of transcription 3
TAMs	Tumor-associated macrophages
TCA	Tricarboxylic acid
TCR	T-cell receptor
TGF-β	Transforming growth factor-beta
TGFBI	Transforming growth factor-beta-induced
TGFBR2	Transforming growth factor-beta receptor 2
TME	Tumor microenvironment
TNF-α	Tumor necrosis factor-alpha
Tregs	Regulatory T cells
VEGF	Vascular endothelial growth factor
YAP1	Yes-associated protein 1