APCs |
Antigen-Presenting Cells |
CAR-T |
Chimeric Antigen Receptor T cells |
CCL |
C-C motif chemokine Ligand |
CRC |
ColoRectal Cancer |
CXCR |
C-X-C chemokine Receptor |
CTLA-4 |
Cytotoxic T-Lymphocyte Antigen 4 |
DCs |
Dendritic Cells |
FcRγ |
FcεRI γ-chain |
FDA |
Food and Drug Administration |
FOG2 |
Friend Of Gata 2 |
FOX |
FOrkhead boX |
HIF |
Hypoxia-Inducible Factor |
IDO |
Indoleamine 2,3-DiOxigenase |
IHC |
ImmunoHistoChemistry |
IL |
InterLeukin |
ITAM |
Immunoreceptor Tyrosine-based Activation Motif |
Ko |
Knock out |
LAG |
Lymphocyte Activation Gene |
mAb |
Monoclonal Antibodies |
MDSCs |
Myeloid-Derived Suppressor Cells |
MHC |
Major Histocompatibility Complex |
miR |
microRNA |
MMP |
Metalloproteinase |
MMR |
MisMatch Repair |
mTOR |
mammalian Target Of Rapamycin |
NK |
Natural Killer |
Nrp-1 |
Neurophilin-1 |
NSCLC |
Non-Small-Cell Lung Cancer |
OS |
Overall Survival |
PD-1 |
Programmed cell Death-1 |
PD-L |
Program Death Ligand |
PDAC |
Pancreatic Ductal AdenoCarcinoma |
PI3K |
PhosphoInositide 3-Kinase |
PIP2 |
PhosphatidylInositol 4,5-bisPhosphate |
PIP3 |
PhosphatidylInositol 3,4,5 trisPhosphate |
PTEN |
Phosphatase and TENsin homolog on chromosome 10 |
Sema4 |
Semaphorin-4 |
SHIP1 |
SH-2 containing inositol 5′ polyphosphatase 1 |
Smo |
Smoothened |
STAT |
Signal Transducer and Activator of Transcription |
TAM |
Tumor-Associated Macrophage |
TGF |
Transforming Growth Factor |
TIGIT |
T cell ImmunoGlobulin and ITIM domain |
TILs |
Tumor-Infiltrating Lymphocytes |
TIM |
T-cell Immunoglobulin Mucin |
TME |
Tumor MicroEnvironment |
TNBC |
Triple Negative Breast Cancer |
TNF |
Tumor Necrosis Factor |
TNM |
Tumor, Node, Metastasis |
TRAIL |
TNF-Related Apoptosis-Inducing Ligand |
Tregs |
regulatory T cells |
VEGF |
Vascular Endothelial Growth Factor |
VISTA |
V-domain Ig Suppressor of T cell Activation |
wt |
Wild Type |