AMD |
age-related macular degeneration |
CNV |
choroidal neovascularization |
POS |
photoreceptors outer segments |
AGEs |
advanced glycation end products |
VEGF |
vascular endothelial growth factor |
VEGFR2 |
vascular endothelial growth factor receptor 2 |
oBRB |
outer blood–retinal barrier |
PEDF |
pigment epithelium-derived factor |
DHA |
docosahexaenoic acid |
DDC |
L-dopa decarboxylase |
DA |
dopamine |
PD |
Parkinson’s disease |
MAO |
monoamine oxidase |
EGFR |
epidermal growth factor receptor |
RUBCN/Rubicon |
RUN domain and cysteine-rich domain-containing Beclin 1-interacting protein |
mTOR |
mammalian/mechanistic target of rapamycin kinase |
Nrf2 |
nuclear factor erythroid 2-related factor 2 |
AMPK |
5’ AMP-activated protein kinase |
TFEB |
transcription factor EB |
ROS |
reactive oxygen species |
PCG1 |
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha |
PUFAs |
polyunsaturated fatty acids |
A2E |
N-retinylidene-N-retinylethanolamine |
ECM |
extracellular matrix |
TXNIP |
thioredoxin-interacting protein |
HIF-1α |
Hypoxia-Inducible Factor 1-alpha |
DAMPs |
danger-associated molecular patterns |
NF-kB |
Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells |
TLRs |
Toll-like receptors |
RAGEs |
advanced glycosylation end product (AGE) receptors |
JAK/STAT |
Janus Kinase/Signal Transducer and Activator of Transcription |
NLPR3 |
inflammasome/NACHT, LRR, and PYD domains-containing protein 3 |
HSP90 |
heat-shock protein 90 |
MMP-2 |
matrix metalloproteinase-2 |
MHC-I |
major histocompatibility complex I |
AT1R |
angiotensin II receptor type 1 |
IFN- |
interferon-gamma |
PTEN |
phosphatase and tensin homolog |
MPOD |
macular pigment optical density |
iNOS |
inducible nitric oxide synthase |
TNF-α |
Tumor Necrosis Factor-alpha |
GA |
geographic atrophy |
RPE |
retinal pigment epithelium |