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. 2020 Aug 3;21(15):5563. doi: 10.3390/ijms21155563
AMD age-related macular degeneration
CNV choroidal neovascularization
POS photoreceptors outer segments
AGEs advanced glycation end products
VEGF vascular endothelial growth factor
VEGFR2 vascular endothelial growth factor receptor 2
oBRB outer blood–retinal barrier
PEDF pigment epithelium-derived factor
DHA docosahexaenoic acid
DDC L-dopa decarboxylase
DA dopamine
PD Parkinson’s disease
MAO monoamine oxidase
EGFR epidermal growth factor receptor
RUBCN/Rubicon RUN domain and cysteine-rich domain-containing Beclin 1-interacting protein
mTOR mammalian/mechanistic target of rapamycin kinase
Nrf2 nuclear factor erythroid 2-related factor 2
AMPK 5’ AMP-activated protein kinase
TFEB transcription factor EB
ROS reactive oxygen species
PCG1 Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
PUFAs polyunsaturated fatty acids
A2E N-retinylidene-N-retinylethanolamine
ECM extracellular matrix
TXNIP thioredoxin-interacting protein
HIF-1α Hypoxia-Inducible Factor 1-alpha
DAMPs danger-associated molecular patterns
NF-kB Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
TLRs Toll-like receptors
RAGEs advanced glycosylation end product (AGE) receptors
JAK/STAT Janus Kinase/Signal Transducer and Activator of Transcription
NLPR3 inflammasome/NACHT, LRR, and PYD domains-containing protein 3
HSP90 heat-shock protein 90
MMP-2 matrix metalloproteinase-2
MHC-I major histocompatibility complex I
AT1R angiotensin II receptor type 1
IFN- interferon-gamma
PTEN phosphatase and tensin homolog
MPOD macular pigment optical density
iNOS inducible nitric oxide synthase
TNF-α Tumor Necrosis Factor-alpha
GA geographic atrophy
RPE retinal pigment epithelium