Table 2.
Characteristics of population-based families carrying CDKN2A mutations, in Australia and the United Kingdom
| Country | Number of families |
Number of probands’ relatives | Relatives, % male |
Relatives with melanoma1 |
Family history of melanoma for proband | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Number (%) of relatives with melanoma in each family | |||||||||||
| Total (average per proband) |
1st degree | 2nd degree | 3rd or higher degree |
0 | 1 | 2 | ≥ 3 | ||||
| United Kingdom | 22 | 322 (14.6) | 122 (38%) | 193 (60%) | 7 (2%) | 56% | 16 (5%) | 14 (64%) | 2 (9%) | 4 (18%) | 2 (9%) |
| Australia | 13 | 223 (17.2) | 67 (30%) | 136 (61%) | 20 (9%) | 54% | 21 (9%) | 3 (23%) | 5 (38%) | 3 (23%) | 2 (15%) |
1
Includes confirmed and unconfirmed reports of melanoma in relatives