Table 4.
Estimates of hazard ratios and age-specific cumulative risk of melanoma from birth, for carriers of a CDKN2A mutation, by region and sex
| Age-specific cumulative risk % (95% CI) for mutation carriers |
||||||
|---|---|---|---|---|---|---|
| Geographic region and sex |
Hazard ratio1 (95% CI) |
To age 40 | To age 50 | To age 60 | To age 70 | To age 80 |
| United Kingdom | ||||||
| All | 87 (50-153) | 9 (5-15) | 16 (10-27) | 26 (16-41) | 35 (22-53) | 45 (29-65) |
| Females | 78 (33-181) | 11 (5-23) | 20 (9-40) | 29 (14-55) | 37 (18-66) | 45 (23-75) |
| Males | 98 (44-215) | 7 (3-15) | 13 (6-26) | 23 (11-43) | 33 (16-58) | 45 (24-73) |
| Australia | ||||||
| All | 31 (20-50) | 11 (7-17) | 20 (13-30) | 30 (20-44) | 41 (28-57) | 52 (37-69) |
| Females | 48 (25-89) | 19 (11-33) | 33 (19-52) | 44 (26-66) | 53 (33-76) | 64 (42-85) |
| Males | 18 (8-41) | 5 (3-12) | 11 (5-23) | 19 (9-37) | 29 (14-53) | 38 (19-66) |
| Brisbane | 9 (2-33) | 4 (1-15) | 9 (3-29) | 14 (4-44) | 21 (6-57) | 28 (9-70) |
| Sydney | 44 (22-88) | 14 (7-26) | 24 (13-43) | 35 (19-58) | 47 (27-72) | 57 (35-82) |
| Melbourne | 49 (24-98) | 15 (8-28) | 24 (13-43) | 36 (20-59) | 47 (27-72) | 58 (35-83) |
CI = confidence interval
1
Hazard ratio for melanoma for mutation carriers compared to the general population. P-values for hazard ratio differences between subgroups are: UK all versus Australia all: 0.008; UK females versus UK males: 0.20; Australian females versus Australian males: 0.07; Brisbane versus Sydney versus Melbourne: 0.02