Table 1.

Select model parameters

Parameter	Description	Value (WT)	Reference/constraint
gsaca	Whole conductance for stretch-activated Ca2+ influx pathway	1500 pS	Fig. 3
βm	MT strain scalar	10	N/A
β0	Minimal MT stain factor	0.01	N/A
β1	MT strain normalizing factor	0.1	N/A
βη	Cooperativity factor for MT strain	2	N/A
ρMT	Unitless MT density	1	N/A
ρNOX2	Unitless NOX2 density	1	N/A
ρWTo	Basal oxidization factor for WT	0	Figs 3 and 4
ρMDXo	Basal oxidization factor for MDX	0.08	Figs 3 and 4
kda	NOX2 rate constant	0.2 s−1	Prosser et al. (2011, 2013b)
kar	NOX2 rate constant	0.25 s−1	Prosser et al. (2011, 2013b)
krd	NOX2 rate constant	1 s−1	Prosser et al. (2011, 2013b)
kad	NOX2 rate constant	1 s−1	Prosser et al. (2011, 2013b)
kdr	NOX2 rate constant	1 s−1	Prosser et al. (2011, 2013b)
kra	NOX2 rate constant	0.05 s−1	Prosser et al. (2011, 2013b)
k12	RyR2 opening rate	0.2 μM−η s−1	Wescott et al. (2016)
k21	RyR2 closing rate	425 s−1	Wescott et al. (2016)
Ap	SERCA density	50 μM	Wescott et al. (2016)
Incx1	Maximal NCX current	500 pA	Wescott et al. (2016)

See Wescott et al. (2016) for additional parameters.