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LM‐031 augments NFR2 and pCREB expression in STZ‐treated 3 × Tg‐AD mice. Expression levels of NRF2, pCREB, and CREB in hippocampus were analyzed by Western blot using GAPDH as a loading control. To normalize, the relative NRF2, pCREB, and CREB of, STZ mice was set as 100%. p values, STZ versus – STZ mice or STZ/LM‐031 versus STZ mice. *: p < .05, and ## and **: p < .01. (one‐way ANOVA with a post hoc Tukey test)
