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. Author manuscript; available in PMC: 2020 Aug 18.
Published in final edited form as: Pharm Res. 2019 Mar 11;36(4):64. doi: 10.1007/s11095-019-2587-6

Table 3.

Histological grading criteria. [18]

Parameters Score Histological features
Inflammation 0 None
1 Slight
2 Moderate
3 Severe

Extent 0 None
1 Mucosa
2 Mucosa and submucosa
3 Transmural

Regeneration 0 Complete regeneration or normal tissue
1 Almost complete regeneration
2 Regeneration with crypt depletion
3 Surface epithelium not intact
4 No tissue repair

Crypt damage 0 None
1 Basal 1/3 damage
2 Basal 2/3 damage
3 Only surface epithelium lost
4 Entire crypt and epithelium lost

Percent involvement 1 1–25%
2 26–50%
3 51–75%
4 76–100%