Skip to main content
. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Eur J Med Chem. 2020 Feb 27;192:112186. doi: 10.1016/j.ejmech.2020.112186

Table 3.

BCL-XL Degraders Designed with Various Linkers Tethering through a Piperazine Ring to Pomalidomide

graphic file with name nihms-1572038-t0027.jpg
Compd Linker IC50 (nM)a Compd Linker IC50 (nM)a
8a graphic file with name nihms-1572038-t0028.jpg 82.0 10a graphic file with name nihms-1572038-t0029.jpg 161
8b graphic file with name nihms-1572038-t0030.jpg 346 10b graphic file with name nihms-1572038-t0031.jpg 211
8c graphic file with name nihms-1572038-t0032.jpg 518 10c graphic file with name nihms-1572038-t0033.jpg 126
8d graphic file with name nihms-1572038-t0034.jpg >2000 11a graphic file with name nihms-1572038-t0035.jpg 118
8e graphic file with name nihms-1572038-t0036.jpg >2000 11b graphic file with name nihms-1572038-t0037.jpg 722
9a graphic file with name nihms-1572038-t0038.jpg 28.3 12a graphic file with name nihms-1572038-t0039.jpg 60.5
9b graphic file with name nihms-1572038-t0040.jpg 43.0 12b graphic file with name nihms-1572038-t0041.jpg 41.4
9c graphic file with name nihms-1572038-t0042.jpg 100 12c graphic file with name nihms-1572038-t0043.jpg 17.3
a

IC50 values are the means of at least three independent experiments; reduction of MOLT-4 cell viability after 48 h treatment.