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. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Eur J Med Chem. 2020 Feb 27;192:112186. doi: 10.1016/j.ejmech.2020.112186

Table 4.

BCL-XL Degraders Designed with Various Linkers Tethering through an N-Methylamino Group to Pomalidomide

graphic file with name nihms-1572038-t0044.jpg
Compd Linker IC50 (nM)a Compd Linker IC50 (nM)a
13a graphic file with name nihms-1572038-t0045.jpg 770 16b graphic file with name nihms-1572038-t0046.jpg 38.7
13b graphic file with name nihms-1572038-t0047.jpg 769 16c graphic file with name nihms-1572038-t0048.jpg 60.9
14a graphic file with name nihms-1572038-t0049.jpg 177 16d graphic file with name nihms-1572038-t0050.jpg 147
14b graphic file with name nihms-1572038-t0051.jpg 179 16e graphic file with name nihms-1572038-t0052.jpg >2000
15a graphic file with name nihms-1572038-t0053.jpg 29.2 17a graphic file with name nihms-1572038-t0054.jpg 35.0
15b graphic file with name nihms-1572038-t0055.jpg 35.0 17b (XZ739) graphic file with name nihms-1572038-t0056.jpg 10.1
16a graphic file with name nihms-1572038-t0057.jpg 32.5 17c graphic file with name nihms-1572038-t0058.jpg 19.3
a

IC50 values are the means of at least three independent experiments; reduction of MOLT-4 cell viability after 48 h treatment.