Table 1.

Characteristics of the studies included in the meta-analysis

First author, year, study	Cohort characteristics	Country	Gender (men/women)	BMI (mean ± SD)	Study design	Genotyping	Sample size	genotype			allele		HWE	PH-W
								CC	GC	GG	G	C
Sood.V 2018 [5]	NAFLD children	India			case control study		69	22	23	24	71	67	no	0.005
	NON-NAFLD						30	21	8	1	10	50	yes	0.82
Stasinou.E 2018 [6]	NAFLD children	Greece			case control study	RFLP	58	8	10	40	90	26	no	0.0001
	NON-NAFLD						91	66	22	3	28	154	yes	0.49
Hudert.C 2018 [7]	NAFLD children	German	54/16	35.9 ± 14.5	case control study	TaqMan	70	20	31	19	69	71	yes	0.339
	NON-NAFLD		123/77				200	118	71	11	93	307	yes	0.94
Lin.Y-C 2014 [8]	NAFLD children	China	555/242	27.0 ± 4.1	case control study	TaqMan	191	58	95	38	171	211	yes	0.93
	NON-NAFLD		115/47	26.75 ± 3.85			606	238	293	75	443	769	yes	0.29
Shang.X-R 2015 [9]	NAFLD children	China	459/406	20.72 ± 3.61	case control study	Mass ARRAY	162	60	74	28	130	194	yes	0.53
	NON-NAFLD			28.8 ± 2.8			865	338	418	109	636	1094	yes	0.24
Bugianesi.E 2017 [10]	NASH	Italy		28.2 ± 3.5	case control study	TaqMan	219	74	101	44	189	249	yes	0.37
	NAFL		41/30	95 ± 6			69	36	30	3	36	102	yes	0.29
Nobili.V 2014 [11]	NASH	Italy	51/30	95 ± 6	case control study	TaqMan	71	48	23
	NAFL		93/56				81	80	1
Valenti.L 2010 [12]	NASH	Italy			case control study	TaqMan	69	1	44	23	90	46	no	0.0002
	NAFL			28.2 ± 3.6			81	64	17	0	17	145	yes	0.29
Mosca.A 2018 [13]	NASH	Italy		27.8 ± 6	case control study	TaqMan	25	5	13	7	27	23	yes	0.82
	NAFL						9	9	0	0	0	18