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. 2020 Aug 17;11:65. doi: 10.1186/s13229-020-00366-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — MSC-exo can cross the BBB and integrate into the cells in the tissue. a Complete sagittal section of Shank3B KO shows MSC-exo are found in the parenchyma and accumulate mainly in the area of the cortex, cerebellum, and some accumulation in the hippocampus (96 h post intranasal administration). b Complete sagittal section of WT shows complete evacuation of MSC-exo from the brain (96 h post intranasal administration). c, d Magnification of the cerebellum and hippocampus tissues of Shank3B KO shows MSC-exo are found in the tissue. e Magnification of the CA1 area with DAPI (blue), PKH26 exosomes (red), and astrocytes (GFAP green)