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Targeting EphA2 in cancer. EphA2’s expression patterns and functional relevance in malignancies make this protein an attractive therapeutic target in cancer. Accordingly, EphA2 overexpression has been targeted with several approaches such as decrease EPHA2 expression, promote EphA2 degradation, block endogenous EphA2 activation, EphA2 as drug delivery target, EphA2-based immunotherapy, and EphA2-based combination therapeutics
