Table 4.
Test efficiency of the Modified Ovarian Sensitivity Index for in vitro fertilization parameters (additional cohort)
| Category | MOSI score | All data (n = 337) | Only normo-responders (n = 255) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Prevalence | Test accuracy | PPV | NPV | Prevalence | Test accuracy | PPV | NPV | ||
| High-quality Embryo on Day 2 (≥6) | 2.1 | 27.3% | 33.2% | 28.6% | 88.5% | 27.1% | 27.1% | 27.1% | N/A |
| 2.6 | 43.4% | 32.0% | 93.5% | 35.7% | 29.4% | 95.8% | |||
| 3.1 | 54.3% | 36.0% | 89.6% | 50.2% | 33.7% | 88.3% | |||
| 3.6 | 68.5% | 45.2% | 86.4% | 69.0% | 45.1% | 85.0% | |||
| 4.1 | 71.8% | 47.1% | 76.2% | 73.3% | 57.1% | 73.8% | |||
| 4.6 | 71.5% | 16.7% | 72.5% | 72.9% | N/A | 72.9% | |||
| Blastocysts (≥6) | 2.0 | 35.9% | 39.5% | 36.9% | 80.0% | 35.7% | 35.7% | 35.7% | N/A |
| 2.5 | 44.8% | 39.1% | 89.5% | 35.7% | 35.7% | N/A | |||
| 3.0 | 54.9% | 43.4% | 81.4% | 49.0% | 39.8% | 76.6% | |||
| 3.5 | 68.0% | 54.0% | 80.7% | 66.3% | 52.1% | 78.3% | |||
| 4.0 | 69.4% | 64.1% | 70.7% | 68.2% | 75.0% | 67.7% | |||
| 4.5 | 65.3 | 70.0% | 65.1% | 64.3% | N/A | 64.3% | |||
| Rate of blastocyst/ova captured (≥35%) | 2.0 | 18.1% | 22.8% | 18.6% | 90.0% | 18.0% | 18.0% | 18.0% | N/A |
| 2.5 | 28.2% | 19.7% | 94.7% | 18.0% | 18.0% | N/A | |||
| 3.0 | 43.0% | 22.1% | 91.2% | 37.6% | 20.4% | 89.1% | |||
| 3.5 | 61.4% | 28.6% | 91.5% | 62.0% | 28.2% | 90.6% | |||
| 4.0 | 74.8% | 31.3% | 85.0% | 79.6% | 35.0% | 83.4% | |||
| 4.5 | 80.7% | 30.0% | 82.3% | 82.0% | N/A | 82.0% | |||
| 4.8 | 81.3% | 0% | 81.8% | 82.0% | N/A | 82.0% | |||
Abbreviations: MOSI modified ovarian sensitivity index, NPV negative predictive value, and PPV Positive predictive value
Bold values are the results based on the cutoff using the highest Youden index based on the Receiver-operating characteristic curve