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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Lancet HIV. 2020 Jul;7(7):e463–e471. doi: 10.1016/S2352-3018(20)30108-9

Table 2.

Effect of vitamin D3 supplementation on all-cause mortality and incident pulmonary tuberculosis outcomes

Vitamin D
No. events / No. randomized at risk# (%)		 Placebo
n / N (%)
No. events / No. randomized at risk (%)		 Hazard ratio (95% CI) p-value*
All-cause mortality 211 / 2001 (10.5) 204 / 1999 (10.2) 1.04 (0.85–1.25) 0.73
Incident pulmonary TB 50 / 1812 (2.8) 64 / 1827 (3.5) 0.78 (0.54–1.13) 0.19
Incident sputum smear-positive pulmonary TB 20 / 1812 (1.1) 37 / 1827 (2.0) 0.54 (0.31–0.92) 0.026
Incident sputum smear-negative pulmonary TB 30 / 1812 (1.6) 27 / 1827 (1.5) 1.12 (0.66–1.88) 0.68
Incident microbiologically confirmed TB (sputum or GeneXpert positive) 22 / 1812 (1.2) 38 / 1827 (2.1) 0.58 (0.34–0.97) 0.039
Incident high bacillary load (≥ 2+) sputum smear-positive pulmonary TB 10 / 1812 (0.6) 27 / 1827 (1.5) 0.37 (0.18–0.76) 0.0067
*

Log-rank test

#

Incident pulmonary TB analyses exclude participants who had pulmonary TB at baseline