Table 2.

GRADE evidence profile

Outcome	Certainty assessment							No. of patients		Effect		Certainty
	Study ID	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	Intervention	Comparator	Relative (95% CI)	Absolute (95% CI)
Mortality	Chen et al. [21]	RCT	Serious	Not serious	Not serious	Very serious	None	0/15	0/15	–		Very low
Failure of virologic clearance	Chen et al. [21]	RCT	Serious	Not serious	Serious	Very serious	None	2/15	1/15	RR 2.0 (0.2–20)		Very low
Clinical improvement	Zhaowei Chen et al. [18]	RCT	Serious	Not serious	Serious	Serious	None	25/31	17/31	RR 1.47 (1.02–2.11)		Very low
Virologic cure	Gautret et al. [17]	Prospective cohort	Very serious	Serious	Not serious	Serious	None	70%	12.5%	RR 16.33 (2.8–95.26)		Very low
Virologic cure	Molina et al. [22]	Single-arm study	Very serious	Serious	Serious	Serious	None	2/11	–	–	–	Very low
Mortality	Molina et al. [22]	Single-arm study	Very serious	Serious	Serious	Serious	None	1/11	–	–	–	Very low
QT interval	Chorin et al. [20]	Single-arm study	Very serious	Serious	Serious	Serious	None	11%	–	–	–	Very low
Mortality	Million et al. [19]	Single-arm, retrospective, cohort study	Very serious	Serious	Serious	Not serious	None	8/1061	–	–	–	Very low
Virologic cure	Million et al. [19]	Single-arm, retrospective, cohort study	Very serious	Serious	Serious	Not serious	None	973/1061	–	–	–	Very low
Mortality	Magognoli et al. [23]	Retrospective, propensity-score-matched cohort	Very serious	Not serious	Not serious	Not serious	None	51/210	18/158	RR 2.49 (1.39–4.47)	–	Very low
Rates of ventilation	Magognoli et al. [23]	Retrospective, propensity-score-matched cohort	Very serious	Not serious	Serious	Not serious	None	21/210	22/158	RR 0.69 (0.36–1.29)	–	Very low
Virologic cure	Tang et al. [24]	Randomized controlled study	Very serious	Serious	Serious	Not serious	None	64/75	61/75	RR 1.33 (0.56–3.16)	–	Very low
Clinical cure	Holshue et al. [28]	Case report	Very serious	Not serious	Not serious	Very serious	None	1/1	–	–	–	Very low
Extubation of mechanical ventilation	Grein et al. [29]	Single-arm, prospective cohort						17/30				Very low
Mortality	Grein et al. [29]	Single-arm, prospective cohort	Very serious	Serious	Serious	Serious	None	7/61	–	–	–	Very low
Body temperature	Wang et al. [36]	Prospective cohort	Very serious	Serious	Serious	Serious	None	2.06 ± 0.28	5.29 ± 0.70	–	–	Very low
Mortality	Lu et al. [37]	Retrospective cohort	Very serious	Serious	Serious	Serious	None	12/31	5/31	RR 3.2 (0.98–10.89)	–	Very low
Body temperature normalization	Shen et al. [38]	Case series	Not serious	Not serious	Very serious	Not serious	None	4/5	–	–	–	Very low
Virologic cure	Shen et al. [38]	Case series	Not serious	Not serious	Very serious	Not serious		5/5	–	–	–	Very low
Clinical cure	Duan et al. [39]	Case series	Not serious	Not serious	Very serious	Not serious		10/10	–	–	–	Very low
Absorption of pulmonary lesions	Duan et al. [39]	Case series	Not serious	Not serious	Very serious	Not serious		10/10	–	–	–	Very low
Virologic cure	Young et al. [40]	Case series	Not serious	Not serious	Very serious	Not serious		2/2/	–	–	–	Very low
Virologic cure	Zhu et al. [44]	RCT	Serious	Not serious	Not serious	Not serious		16/16	19/34	RR 26.23 (1.45–472.69)	–	Very low
Virologic cure	Li et al. [45]	RCT	Serious	Not serious	Serious	Serious		25/69	7/17	RR 0.81 (0.27–2.39)	–	Very low
Days to normalization of body temperature	Ye et al. [43]	Prospective cohort	Very serious	Not serious	Serious	Not serious		4.8 ± 1.94	7.3 ± 1.53	–	–	Very low
Body temperature normalization	Xu et al. [41]	Prospective cohort	Very serious	Not serious	Serious	Not serious		20/20	–	–	–	Very low
Virologic cure	Luna et al. [42]	Case report	Very serious	Very serious	Not serious	Not serious		1/1	–	–	–	Very low

RR relative risk