| The quality of early evidence favoring the different treatment options needs to be apprised for informed decision-making. |
| We performed a comprehensive systematic literature search and appraisal of early clinical evidence for the therapeutic management of SARS-CoV-2 infection. |
| An overview on the difference in recommendations and the evidence base for arriving at the recommendations by various guidelines have been provided. |
| The insights from quality of early evidence will also assist in mounting a better response to future pandemics. |
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