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. 2020 Jul 8;21(1):1079. doi: 10.4102/sajhivmed.v21i1.1079

TABLE 2.

Infant HIV post-exposure prophylaxis given at birth.

Risk category Indications Infant prophylaxis
  • Low-risk infant at birth, whether breastfed or exclusively formula fed

  • Maternal VL at delivery < 1000 copies/mL

  • Infant NVP at birth and then daily for six weeks

  • High-risk infant at birth in the breastfed infant

  • Mother not on ART at delivery, or

  • Infant NVP for a minimum of 12 weeks. Infant NVP only discontinued after confirmation of maternal VL being < 1000 copies/mL, and or until four weeks after cessation of all breastfeeding.

  • Mother on ART with HIV VL ≥ 1000 copies/mL at delivery, or prior to 12 weeks

  • No HIV VL result available at delivery or prior to 12 weeks

  • Infant AZT twice daily for six weeks

  • High-risk infant at birth in the infant exclusively formula fed from birth

  • Mother not on ART at delivery, or

  • Infant NVP at birth and then daily for six weeks (provided that avoiding breastfeeding is documented and sustained), and

  • Mother on ART with HIV VL ≥ 1000 copies/mL at delivery, or prior to 12 weeks

  • Infant AZT twice daily for six weeks

  • No HIV VL result available at delivery or prior to 12 weeks

ART, antiretroviral therapy; AZT, zidovudine; NVP, nevirapine; VL, viral load; HIV, human immunodeficiency virus.