Comparison 5. Chromium (1000 μg) versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in weight	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 12 weeks	2	50	Mean Difference (IV, Fixed, 95% CI)	‐0.66 [‐7.25, 5.93]
2 Change in body mass index	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 6 months	2	90	Mean Difference (IV, Random, 95% CI)	0.11 [‐0.08, 0.30]
2.2 12 weeks	2	99	Mean Difference (IV, Random, 95% CI)	0.28 [‐0.01, 0.58]
3 Change in percent body fat	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.1 6 months	1	58	Mean Difference (IV, Random, 95% CI)	1.1 [‐0.35, 2.55]
3.2 12 weeks	3	117	Mean Difference (IV, Random, 95% CI)	0.93 [‐0.35, 2.21]
4 Change in waist circumference	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
4.1 12 weeks	1		Mean Difference (IV, Fixed, 95% CI)	‐1.60 [‐6.53, 3.33]
5 Change in fasting glucose	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
5.1 12 weeks	2	99	Mean Difference (IV, Random, 95% CI)	‐0.25 [‐1.29, 0.80]
5.2 6 months	1	58	Mean Difference (IV, Random, 95% CI)	0.0 [‐2.14, 2.14]
6 Change in total cholesterol	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 6 months	2	90	Mean Difference (IV, Random, 95% CI)	‐0.07 [‐0.68, 0.53]
6.2 12 weeks	1	67	Mean Difference (IV, Random, 95% CI)	‐1.80 [‐8.03, 4.43]
7 Change in triacylglycerol	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
7.1 6 months	2	90	Mean Difference (IV, Random, 95% CI)	‐1.16 [‐3.19, 0.87]
7.2 12 weeks	1	67	Mean Difference (IV, Random, 95% CI)	‐3.7 [‐13.38, 5.98]
8 Change in basal metabolic rate	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
8.1 12 weeks	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
9 Adverse events	3	134	Risk Ratio (M‐H, Random, 95% CI)	1.75 [0.30, 10.43]
9.1 6 months	2	94	Risk Ratio (M‐H, Random, 95% CI)	4.03 [0.46, 35.11]
9.2 12 weeks	1	40	Risk Ratio (M‐H, Random, 95% CI)	0.30 [0.01, 7.02]
10 Change in systolic blood pressure	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
10.1 12 weeks	1	67	Mean Difference (IV, Fixed, 95% CI)	2.1 [‐0.95, 5.15]
10.2 6 months	2	90	Mean Difference (IV, Fixed, 95% CI)	2.88 [‐0.36, 6.12]
11 Change in diastolic blood pressure	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
11.1 12 weeks	1	67	Mean Difference (IV, Random, 95% CI)	0.9 [‐2.01, 3.81]
11.2 6 months	2	90	Mean Difference (IV, Random, 95% CI)	2.83 [‐0.88, 6.55]