Volpe 2001.
| Methods | Parallel randomised controlled clinical trial | |
| Participants |
Inclusion criteria: 44 female participants, with a BMI between 27 and 41 kg/m2, between 27 and 51 years of age, premenopausal, sedentary, not taking any dietary supplements, not taking any vitamin or mineral supplements containing chromium, not on a weight‐loss programme, not taking any weight loss supplements, non‐smoking and with no history of chronic diseases or recent acute illness. Participants were asked not to alter their dietary habits during the course of the study Exclusion criteria: not stated Diagnostic criteria: BMI |
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| Interventions |
Number of study centres: 1 Treatment before study: not stated Titration period: not stated |
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| Outcomes | Outcomes reported in abstract of publication: body composition, resting metabolic rate, fasting plasma glucose, serum insulin, plasma glucagon, serum C‐peptide and serum lipid concentrations or iron and zinc indices, serum total cholesterol concentration, exercise training | |
| Study details |
Run‐in period: 12 weeks Study terminated before regular end: no |
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| Publication details |
Language of publication: English Commercial and non‐commercial funding: "the authors would like to thank Nutrition 21 (San Diego, CA) for funding this project. This research is based upon work partially supported by the Cooperative State Research Extension, Education Service, U.S. Department of Agriculture Experiment Station, under Project No. MAS00757 Manuscript No. 3280" Publication status: peer review journal |
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| Stated aim for study | Quote: "To investigate the effect of chromium picolinate (CP) supplementation on body composition, resting metabolic rate (RMR), selected biochemical parameters and iron and zinc status in moderately obese women participating in a 12‐week exercise program" | |
| Notes | Abbreviations: BMI: body mass index | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Quote: "Forty‐four free‐living females were assigned, in a stratified randomised manner based on their BMI, to one of two groups" Comment: no other details given |
| Allocation concealment (selection bias) | Unclear risk | Comment: not reported |
| Blinding of participants and personnel (performance bias) Objective outcomes | Unclear risk | Quote from publication: "double‐blind" Comment: no other details given |
| Blinding of participants and personnel (performance bias) Subjective outcomes | Low risk | Comment: no subjective outcomes |
| Blinding of outcome assessment (detection bias) Objective outcomes | Low risk | Comment: no details provided |
| Blinding of outcome assessment (detection bias) Subjective outcomes | Unclear risk | Comment: no details provided |
| Incomplete outcome data (attrition bias) Objective outcomes | Unclear risk | Quote: "Thirty‐seven of the initial 44 people (84%) completed this study. Sixteen people reported forgetting to take their capsules and 13 people missed exercise training; however, no people reported forgetting to take the capsules more than five days (average 3 days) during the study period. Furthermore, none of these people missed exercise training more than four times (average 3) during the entire study. Two people did have minor problems with their knees or ankles, so they were unable to perform all of the specified weight training exercises (e.g. leg extension and calf raises)" |
| Incomplete outcome data (attrition bias) Subjective outcomes | Low risk | Comment: no subjective outcome |
| Selective reporting (reporting bias) | Low risk | Comment: all of the outcomes listed in the methods section were reported as results |
| Other bias | Unclear risk | Comment: the trial had a commercial source of funding possibly creating a risk of bias |