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. 2020 Aug 11;7:147. doi: 10.3389/fmolb.2020.00147

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Copyright © 2020 Tang, Dong, Liu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NEAT1 was upregulated in IVDD in vivo and in vitro and regulated ECM metabolism and apoptosis of degenerative HNPC cells. The expression of NEAT1 in vivo (A) and AGE or AGE + NEAT1 siRNA-treated HNPC cells was detected by real-time PCR (B); there were three replicates in each group. (C–F) The expressions of collagen-II, TIMP-1, MMP-3, and cleaved-caspase-3 were analyzed by Western blot, respectively; there were three replicates in each group. (G) Hoechst staining was performed to observe the apoptosis of HNPC cells; there were five replicates in each group. *P < 0.05 vs. control group; #P < 0.05 vs. AGE group; &P < 0.05 vs. AGE + NEAT1 siRNAs group.