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. 2020 Aug 11;7:147. doi: 10.3389/fmolb.2020.00147

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Copyright © 2020 Tang, Dong, Liu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of NEAT1 upregulates miR-195a to reverse BAX/BAK-dependent apoptosis in the IVDD rat model. (A,B) Real-time PCR was used to measure the miR-195a or NEAT1 expression in the IVDD rat model; there were three replicates in each group. (C,D) The expressions of BAX and BAK were analyzed by Western blot, respectively; there were three replicates in each group. (E) Tunel staining was used to detect the apoptosis of nucleus pulposus cells in the IVDD rat model. *P < 0.05 vs. control group; #P < 0.05 vs. IVDD group; &P < 0.05 vs. IVDD + NEAT1 siRNAs group.