4.

静息心率及常见慢性病双表型遗传度

Bivariate heritability of resting heart rate and common chronic diseases

Variables	Environmental correlation	Pa	Genetic correlation (95%CI)	Pb	Pc	Phenotypic correlation	Pd
a, testing the difference between the environmental correlation and 0; b, testing the difference between the genetic correlation and 0; c, testing the difference between the genetic correlation and 1 or -1; d, testing the difference between the phenotypic correlation and 0; e, inverse normal transformation was applied for the variables not following normal distribution. All variables were adjusted for gender, age, age×gender, age2, gender×age2. SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CI, confidence interval.
Hypertension	0.163	0.13	-0.086 (-0.515-0.343)	0.70	<0.05	0.080	<0.05
Diabetes	-0.108	0.41	0.795 (0.120-1.000)	<0.05	0.31	0.159	<0.05
Dyslipidemia	0.297	0.08	-0.170 (-0.467-0.128)	0.25	<0.05	0.034	0.29
SBP	0.126	0.13	-0.188 (-0.486-0.110)	0.30	<0.05	0.026	0.32
DBP	0.344	<0.05	-0.214 (-0.625-0.197)	0.27	<0.05	0.187	<0.05
Fasting glucosee	0.068	0.40	0.485 (0.181-0.788)	<0.05	<0.05	0.203	<0.05
Total cholesterole	0.100	0.23	-0.151 (-0.463-0.161)	0.34	<0.05	0.011	0.68
Triglyceridee	0.185	<0.05	-0.129 (-0.413-0.156)	0.37	<0.05	0.054	<0.05
HDL-Ce	-0.015	0.91	0.022 (-0.204-0.249)	0.85	<0.05	0.005	0.83
LDL-C	0.051	0.52	-0.171 (-0.505-0.162)	0.32	<0.05	-0.021	0.41