3.

546例结直肠间质瘤多因素预后分析

Multivariate survival analyses of 546 patients with colorectal stromal tumor

Variables	n	CSS		P	OS		P
		HR	95%CI		HR	95%CI
*, tumor size was not collected in SEER database before 2004; SEER, surveillance, epidemiology, and end results; LNM, lymph node metastasis; CSS, cancer-specific survival; OS, overall survival; HR, hazard ratio; CI, confidence interval.
Age/years
≤ 64	273	1			1
> 64	273	2.53	1.71-3.73	< 0.001	3.82	2.83-5.14	< 0.001
Gender
Male	302	1			1
Female	244	0.81	0.55-1.19	0.284	0.83	0.62-1.09	0.182
Marital status
Married	321	1			1
Single/divorced	192	1.71	1.14-2.57	0.010	1.51	1.12-2.03	0.006
Unknown	33	0.67	0.23-1.92	0.456	0.74	0.38-1.46	0.391
Ethnicity
Caucasian	361	1			1
African-American	93	0.79	0.43-1.45	0.449	0.90	0.60-1.36	0.618
Other/Unknown	92	0.93	0.55-1.58	0.788	0.76	0.51-1.14	0.191
Date range/year
1992-2007	276	1			1
2008-2015	270	0.95	0.56-1.59	0.834	1.22	0.84-1.76	0.295
SEER registry in America
Eastern	238	1			1
Western	308	1.46	0.97-2.20	0.073	1.39	1.04-1.86	0.027
Tumor location
Colon	241	1			1
Rectum	280	0.58	0.38-0.89	0.012	0.67	0.50-0.91	0.010
Unknown	25	0.50	0.20-1.23	0.129	0.70	0.39-1.24	0.219
Surgery or not
No/Unknown	118	1			1
Surgery	428	0.40	0.24-0.70	0.001	0.46	0.32-0.68	< 0.001
Differentiation grade
Ⅰ	35	1			1
Ⅱ	56	2.07	0.40-10.71	0.385	1.74	0.64-4.73	0.274
Ⅲ	34	5.54	1.15-26.59	0.032	4.18	1.58-11.05	0.004
Ⅳ	54	7.75	1.67-35.94	0.009	6.22	2.45-15.82	< 0.001
Unknown	367	3.90	0.88-17.20	0.072	3.09	1.28-7.47	0.012
Tumor size/cm*
≤ 2	65	1			1
> 2-5	89	1.72	0.45-6.54	0.423	1.23	0.57-2.68	0.603
> 5-10	120	2.03	0.58-7.14	0.268	1.49	0.72-3.08	0.286
> 10	50	3.11	0.85-11.30	0.085	1.87	0.86-4.06	0.115
Unknown	222	3.84	1.13-13.06	0.031	2.81	1.39-5.67	0.004
Lymphadenectomy
No/Unknown	342	1			1
Yes	204	1.00	0.63-1.60	0.987	0.90	0.64-1.25	0.519
LNM
Negative/Unknown	527	1			1
Positive	19	2.88	1.41-5.88	0.004	2.50	1.41-4.42	0.002
Distant metastasis
No/Unknown	499	1			1
Yes	47	2.55	1.48-4.40	0.001	1.91	1.24-2.95	0.003