4.

174例组织学分级和肿瘤部位明确的结直肠间质瘤多因素预后分析

Multivariate survival analyses of 174 patients diagnosed as colorectal stromal tumor with histological grade and tumor location

Variables	n	CSS		P	OS		P
		HR	95%CI		HR	95%CI
*, tumor size was not collected in SEER database before 2004; SEER, surveillance, epidemiology, and end results; LNM, lymph node metastasis; CSS, cancer-specific survival; OS, overall survival; HR, hazard ratio; CI, confidence interval.
Age/years
≤ 64	83	1			1
> 64	91	2.27	1.05-4.91	0.037	4.97	2.70-9.15	< 0.001
Gender
Male	89	1			1
Female	85	1.02	0.48-2.18	0.963	1.12	0.64-1.98	0.696
Marital status
Married	107	1			1
Other	67	0.58	0.24-1.38	0.215	0.99	0.55-1.80	0.972
Ethnicity
Caucasian	121	1			1
African-American	28	0.69	0.21-2.35	0.557	0.51	0.20-1.27	0.149
Other/Unknown	25	1.43	0.48-4.21	0.520	0.69	0.27-1.77	0.441
Date range/year
1992-2007	86	1			1
2008-2015	88	0.36	0.10-1.31	0.120	0.76	0.28-2.08	0.589
SEER registry in America
1992-2007	74	1			1
2008-2015	100	0.92	0.42-2.02	0.827	1.08	0.61-1.93	0.795
Tumor location
Colon	91	1			1
Rectum	83	0.43	0.19-0.97	0.041	0.58	0.34-1.02	0.057
Surgery or not
No/Unknown	13	1			1
Surgery	161	0.15	0.04-0.58	0.006	0.29	0.11-0.81	0.018
Differentiation grade
Ⅰ	34	1			1
Ⅱ	54	2.93	0.54-15.96	0.213	2.35	0.77-7.18	0.133
Ⅲ	32	7.93	1.47-42.75	0.016	4.39	1.43-13.47	0.010
Ⅳ	54	8.59	1.73-42.57	0.008	7.02	2.38-20.70	< 0.001
Tumor size/cm*
≤ 2	27	1			1
> 2-5	30	0.46	0.07-2.91	0.412	0.77	0.14-4.34	0.766
> 5-10	33	0.41	0.06-2.93	0.378	1.56	0.28-8.59	0.610
> 10	14	0.72	0.09-5.66	0.754	1.81	0.32-10.32	0.506
Unknown	70	0.29	0.03-2.49	0.258	1.23	0.19-7.88	0.826
Lymphadenectomy
No/Unknown	92	1			1
Yes	82	2.14	0.91-5.04	0.083	1.25	0.66-2.36	0.491
LNM
Negative/Unknown	164	1			1
Positive	10	1.30	0.45-3.72	0.631	1.57	0.64-3.85	0.322
Distant metastasis
No/Unknown	155	1			1
Yes	19	2.19	0.94-5.11	0.070	1.64	0.82-3.25	0.159