2.
血清细胞因子表达谱在SSc ILD(+)、SSc Scl-70(+)组中的变化/(ng/L), 中位数(四分位距)
Altered serum cytokine expression profiles in SSc ILD(+)、SSc Scl-70(+) groups/(ng/L), Median (IQR)
| Cytokine | SSc ILD(-) (n=15) |
SSc ILD(+) (n=15) |
P value [ILD(-) vs. ILD(+)] |
SSc Scl-70(-) (n=10) |
SSc Scl-70(+) (n=20) |
P value [Scl-70(-) vs. Scl-70(+)] |
| ILD, interstitial lung disease; other abbreviations as in Table 1. | ||||||
| BASIC FGF | 88.51 (42.70) | 99.08 (51.46) | >0.05 | 77.49 (40.47) | 89.70 (50.58) | >0.05 |
| Eotaxin | 172.10 (140.60) | 185.40 (195.20) | >0.05 | 158.40 (402.00) | 188.60 (179.00) | >0.05 |
| G-CSF | 122.40 (128.54) | 112.00 (97.04) | >0.05 | 105.40 (230.59) | 115.90 (89.78) | >0.05 |
| GM-CSF | 52.97 (86.94) | 121.60 (136.55) | >0.05 | 49.65 (143.35) | 53.17 (122.49) | >0.05 |
| IFN-γ | 205.90 (131.00) | 184.00 (188.80) | >0.05 | 238.10 (943.10) | 187.70 (114.80) | >0.05 |
| IL-12P70 | 36.59 (44.73) | 47.48 (34.56) | >0.05 | 50.77 (186.11) | 45.89 (46.69) | >0.05 |
| IL-1β | 6.30 (5.34) | 9.23 (23.73) | >0.05 | 6.58 (40.19) | 7.05 (6.57) | >0.05 |
| IL-1ra | 460.40 (508.50) | 502.90 (792.10) | >0.05 | 500.90 (6421.90) | 456.30 (524.80) | >0.05 |
| IL-6 | 35.74 (16.38) | 36.27 (119.28) | >0.05 | 27.34 (170.27) | 36.36 (33.49) | >0.05 |
| IP-10 | 1 418.00 (2 969.90) | 1 182.00 (2 306.60) | >0.05 | 1 878.00 (2 964.00) | 1 030.00 (2 196.60) | 0.039 |
| MCP-1 | 180.40 (179.90) | 323.10 (571.20) | >0.05 | 175.00 (216.12) | 296.90 (499.10) | >0.05 |
| TNF-α | 71.00 (39.17) | 52.80 (118.41) | >0.05 | 51.18 (315.81) | 69.48 (41.94) | >0.05 |
| VEGF | 193.70 (210.20) | 298.10 (388.80) | >0.05 | 275.20 (428.40) | 176.30 (232.30) | >0.05 |
| IL-13 | 24.73 (83.62) | 15.12 (36.66) | >0.05 | 18.94 (76.56) | 17.51 (55.58) | >0.05 |
| IL-7 | 18.19 (18.71) | 19.61 (12.01) | >0.05 | 18.02 (57.74) | 21.20 (15.01) | >0.05 |
| RANTES | 45 504.00 (74 609.00) | 59 759.00 (77 217.00) | >0.05 | 78 450.00 (76 739.00) | 38 953.00 (75 650.00) | >0.05 |
| IL-10 | 18.28 (11.81) | 23.40 (13.45) | >0.05 | 14.85 (156.50) | 21.64 (14.77) | >0.05 |
| IL-15 | 2.03 (0.05) | 18.20 (172.97) | 0.024 | 2.03 (63.31) | 2.03 (25.19) | >0.05 |
| IL-17A | 122.30 (66.79) | 145.20 (112.53) | >0.05 | 123.90 (43.10) | 134.50 (73.82) | >0.05 |
| IL-2 | 2.84 (16.57) | 5.95 (34.50) | >0.05 | 4.36 (180.43) | 5.08 (29.21) | >0.05 |
| MIP-1α | 6.76 (3.18) | 6.46 (20.36) | >0.05 | 6.51 (6.51) | 7.74 (4.39) | >0.05 |
| IL-4 | 6.23 (4.63) | 5.72 (3.04) | >0.05 | 6.05 (10.81) | 5.85 (3.51) | >0.05 |
| IL-5 | 3.21 (3.90) | 3.34 (4.84) | >0.05 | 4.09 (10.88) | 3.21 (3.21) | >0.05 |
| IL-8 | 37.45 (21.89) | 49.71 (47.20) | >0.05 | 40.31 (58.24) | 41.05 (28.72) | >0.05 |
| IL-9 | 36.22 (35.10) | 35.86 (30.29) | >0.05 | 33.01 (30.67) | 38.56 (29.77) | >0.05 |
| MIP-1β | 260.70 (285.40) | 310.60 (420.10) | >0.05 | 312.30 (293.10) | 290.60 (243.80) | >0.05 |
| PDGF-BB | 4 359.00 (3 072.00) | 5 043.00 (3 128.00) | >0.05 | 4 827.00 (3 340.00) | 4 701.00 (2 958.00) | >0.05 |