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rs1625895基因多态性与DLBCL患者临床病理学特征的关系

DLBCL patients’ characteristics and their correlations with the genotype of rs1625895

Clinical parameters	n	Genotype		χ2	P
		AA/AG	GG
DLBCL, diffuse large B-cell lymphoma; GCB, germinal center B-cell; non-GCB, non-germinal center B-cell; ECOG, Eastern Cooperative Oncology Group; IPI, international prognostic index; LDH, lactate dehydrogenase; β2-MG, β2-microglobulin; ESR, erythrocyte sedimentation rate; CHOP, cyclophosphoramide, doxorubicin, vincristine, prednisone; R-CHOP, rituximab, cyclophosphoramide, doxorubicin, vincristine, prednisone; B symptoms, develop any of the following symptoms: unexplained recurrent fever (often above 38 ℃), night sweats, and unexplained weight loss of 10% within 6 months.
Age/years
≤60	241	22	219	0.046	0.830
>60	143	14	129
Gender
Male	197	18	179	0.027	0.870
Female	187	18	169
Subtype (no data were available for 39 patients)
GCB	102	13	89	1.693	0.193
Non-GCB	243	20	223
Ki67 (no data were available for 27 patients)
≤75%	171	16	155	0.062	0.803
>75%	186	16	170
Stage (no data were available for 1 patient)
Ⅰ-Ⅱ	178	19	159	0.635	0.426
Ⅲ-Ⅳ	205	17	188
B symptoms
Negative	252	25	227	0.257	0.612
Positive	132	11	121
ECOG score
0-1	344	32	312	0.021	0.886
2-3	40	4	36
IPI score
0-2	270	26	244	0.069	0.792
3-5	114	10	104
LDH (no data were available for 2 patients)
≤240/ IU/L	221	22	199	0.173	0.677
>240/ IU/L	161	14	147
β2-MG (no data were available for 15 patients)
Negative	272	28	244	0.789	0.374
Positive	97	7	90
ESR (no data were available for 14 patients)
Negative	162	12	150	0.810	0.368
Positive	208	21	187
Treatment
CHOP	118	11	107	0.001	0.981
R-CHOP	266	25	241