1.
细胞生长抑制活性
The inhibitory activities in cell proliferation assay
| Cell lines | Cancer type | HER2 level | IC50 /(nmol/L) | |||||
| Anti-HER2-ADC | Ado-trastuzumab emtansine | AS269 | pAF-AS269 | Paclitaxel | ||||
| HER2, human epidermal growth factor receptor 2; mAb, monoclonal antibody; ADC, antibody drug conjugate. | ||||||||
| MDA-MB-468 | Breast cancer | 127 | >30 | 10.160 | >30 | >30 | 6.857 | |
| MCF-7 | 7637 | >30 | >30 | >30 | >30 | 3.017 | ||
| MDA-MB-231 | 7737 | >30 | 19.960 | >30 | >30 | 6.286 | ||
| BT-474 | 428877 | 0.050 | 0.180 | >30 | >30 | 10.280 | ||
| HCC1954 | 448095 | 0.125 | 0.294 | >30 | >30 | 11.500 | ||
| Calu-3 | Lung cancer | 537491 | 0.161 | 4.557 | >30 | >30 | 12.950 | |
| SK-BR-3 | Breast cancer | 719797 | 0.017 | 0.044 | >30 | >30 | 6.468 | |
| NCI-N87 | Gastric cancer | 748406 | 0.017 | 0.032 | >30 | >30 | 7.189 | |
| SK-OV-3 | Ovarian cancer | 799943 | 0.046 | 0.065 | >30 | >30 | 8.475 | |