3.
IMNM不同抗体组间肌肉病理特征比较
Comparisons of pathological features of different serological subgroups of IMNM
| Features | IMNM (n=104) | Anti-SRP (n=47) | Anti-HMGCR (n=23) | MSAs negative (n=34) | P |
| MHC-Ⅰ, major histocompatibility complex class Ⅰ; MAC, membrane attack complex; other abbreviations as in Table 1. Date are shown as n(%). *P<0.017, between anti-SRP /anti-HMGCR group and MSAs negative group; # P<0.017, between anti-SRP and MSAs negative group; △ P<0.017, between anti-HMGCR and MSAs group. | |||||
| Muscle fibre | |||||
| Necrosis | 98 (94.2) | 43 (91.5) | 21 (91.3) | 34 (100.0) | 0.213 |
| Regeneration | 70 (67.3) | 33 (70.2) | 11 (47.8) | 26 (76.5) | 0.066 |
| Phagocytosis | 68 (65.4) | 27 (57.4) | 14 (60.9) | 27 (79.4) | 0.107 |
| Connective tissue proliferation | 36 (34.6) | 17 (36.2) | 8 (34.8) | 11 (32.4) | 0.938 |
| MHC-Ⅰ expression on sarcolemma | 82 (78.8) | 35 (74.5) | 17(73.9) | 30 (88.2) | 0.263 |
| Partial expression | 56 (53.8) | 24 (51.1) | 11 (47.8) | 21 (61.8) | 0.512 |
| Diffuse expression | 26 (25.0) | 11 (23.4) | 6 (26.1) | 9 (26.5) | 0.953 |
| Inflammation infiltration | |||||
| CD4+T cell | 85 (81.7) | 35 (74.5) | 18 (78.3) | 32 (94.1) | 0.045 |
| Endomysial | 71 (68.3) | 27 (57.4) | 14 (60.9) | 30 (88.2) | 0.009* |
| Perivascular | 30 (28.8) | 17 (36.2) | 6 (26.1) | 7 (20.6) | 0.295 |
| CD8+T cell | 57 (54.8) | 21 (44.7) | 11 (47.8) | 25 (73.5) | 0.027# |
| Endomysial | 48 (46.2) | 17 (36.2) | 8 (34.8) | 23 (67.6) | 0.009* |
| Perivascular | 17 (16.3) | 8 (17.0) | 4 (17.4) | 5 (14.7) | 0.951 |
| CD20+B cell | 7 (6.7) | 2 (4.3) | 1 (4.3) | 4 (11.8) | 0.361 |
| Endomysial | 4 (3.8) | 1 (2.1) | 0 | 3 (8.8) | 0.168 |
| Perivascular | 3 (2.9) | 1(2.1) | 1 (4.3) | 1 (2.9) | 0.124 |
| CD68+ macrophage | 79/99 (79.8) | 35/44 (79.5) | 11/21 (52.4) | 32 (94.1) | 0.002△ |
| Endomysial | 65/99 (65.7) | 26/44 (59.1) | 8/21 (38.1) | 31 (91.2) | <0.001* |
| Perivascular | 24/99 (24.2) | 18/44 (40.9) | 3/21 (15.0) | 3 (8.8) | 0.003# |
| MAC | 77/99 (77.8) | 34/44 (77.3) | 11/21 (52.4) | 32 (94.1) | 0.001△ |
| Sarcolemma | 55/99 (55.6) | 20/44 (45.5) | 9/21 (42.9) | 26 (76.5) | 0.015* |
| Sarcoplasm | 18/99 (18.2) | 8/44 (18.2) | 3/21 (14.3) | 7 (20.6) | 0.841 |
| Capillaries | 31/99 (31.3) | 19/44 (43.2) | 4/21 (19.0) | 8 (23.5) | 0.070 |