2.
抗CarP抗体阳性组与抗CarP抗体阴性组SLE患者临床及实验室指标差异
Comparison of clinical and laboratory features between patients with anti-CarP and those without anti-CarP antibodies
| Items | Anti-CarP IgG(+), n=23 | Anti-CarP IgG(-), n=82 | P |
| PLT, platelet; WBC, white blood cell; RBC, red blood cell. ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; C3, complement 3; C4, complement 4; RF, rheumatoid factor; ANA, antinuclear antibody; SLEDAI, systemic lupus erythematosus disease activity index. | |||
| Women, n (%) | 21(91.3) | 74(90.2) | - |
| Age/years, x±s | 34.86±12.82 | 33.91±11.52 | 0.733 |
| Disease duration/ years, median (range) | 2(0-22) | 0.08(6-27) | 0.034 |
| Fever (>38℃), n (%) | 15(65.2) | 36(43.9) | 0.058 |
| Rash, n (%) | 8(34.8) | 31(37.8) | 0.496 |
| Alopecia, n (%) | 10(43.5) | 33(40.2) | 0.481 |
| Oral ulcer, n (%) | 2(8.7) | 20(24.4) | 0.084 |
| Arthritis, n (%) | 5(21.7) | 17(20.7) | 0.561 |
| Serositis, n (%) | 1(4.3) | 4(4.9) | 0.716 |
| Neuropsychiatric symptom, n (%) | 1(4.3) | 6(7.3) | 0.521 |
| ESR/(mm/h), median (range) | 78(11-126) | 23(1-137) | <0.000 1 |
| CRP/(mg/L), median (range) | 6.9(1-69) | 2.9(1-89) | 0.034 |
| C3/(g/L), x±s | 0.41±0.24 | 0.68±0.29 | <0.000 1 |
| C4/(g/L), median (range) | 0.05(0.02-0.34) | 0.13(0-0.34) | <0.000 1 |
| RF/(IU/mL), median (range) | 27.2(20-603) | 20(18-201) | <0.000 1 |
| Anti-Sm, n (%) | 4(17.4) | 9(10.9) | 0.671 |
| ANA, n (%) | 22(95.7) | 75(91.5) | 1.0 |
| SLEDAI, median (range) | 8(3-13) | 8(0-50) | 0.537 |
| Anti-cardiolipin/(RU/mL), median (range) | 9.6(0.1-133.6) | 5.7(0.1-108.9) | 0.003 |
| Anti-dsDNA/(IU/mL), median (range) | 416.6 (51.6-1 012.7) | 133.8 (0.1-1 040.4) | 0.002 |
| Anti-nuclesome/(IU/mL), median (range) | 41.65(5-200) | 42.99(1-200) | 0.287 |
| Anti-ribosomal P protein/(IU/mL), median (range) | 12.8(2-143) | 8.8(0-200) | 0.801 |
| D-dipolymer/(μg/L), median (range) | 779(38-6 920) | 197(14-2 398) | 0.001 |
| IgA/(g/mL), x±s | 3.42±1.96 | 2.27±1.19 | 0.001 |
| IgG/(g/mL), x±s | 24.53±10.57 | 12.25±5.43 | <0.000 1 |
| IgM/(g/mL), median (range) | 0.74(0.08-2.39) | 0.65(0.11-3.96) | 0.151 |
| PLT/(×109/L), x±s | 186.59±99.67 | 163.41±72.95 | 0.219 |
| WBC/(×109/L), x±s | 5.63±2.75 | 5.83±2.78 | 0.770 |
| RBC/ (×1012/L), x±s | 3.17±0.58 | 3.66±0.80 | 0.007 |
| Hemoglobin/(g/mL), x±s | 95.60±14.17 | 113.99±20.82 | <0.000 1 |
| Uric acid/(μmol/L), x±s | 326.5±151.3 | 340.7±116.0 | 0.639 |
| Blood urea/(mmol/L), median (range) | 4.65(2.02-25.37) | 5.35 (1.98-27.14) | 0.731 |
| Blood creatinine/(μmol/L), median (range) | 59(33-260) | 57(32-2 499) | 0.875 |
| Proteinuria for 24 h/(g/d), median (range) | 0.72(0.04-6.87) | 0.53(0-95.70) | 0.433 |