Figure 1.

RNA stem loops common to the 5′UTRs in the mRNAs for L- and H-ferritin and the key neurodegenerative transcripts for the amyloid precursor protein, alpha synuclein and Prion Protein. (A) IRE-like AGU/AGA tri-loops and potential iron-regulatory protein binding motifs in key neurodegenerative disease transcripts for human and mouse APP and SNCA mRNAs and in the human PrP and ferritin- L and H transcripts; further links between iron and AD and PD. (B) Organization of the positions of the IRE-like RNA stem loops in the 5′untranslated regions of human and mouse APP mRNAs and in the human PrP, SNCA and ferritin- L and H transcripts. (C) Alignment of the central AGU and AGA motifs in the 5′UTRs of human APP, αsyn and PrP transcripts relative to those for H- and H-ferritin.