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. 2020 Sep;27(9):380–389. doi: 10.1101/lm.050666.119

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© 2020 Fontaine et al.; Published by Cold Spring Harbor Laboratory Press

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Figure 6. — Direct pharmacological activation of CB1 receptors induces LTD in the DG. (A) LTD was measured as the average percentage of change in the fEPSP slope relative to baseline for minutes 75–80 as a result of the wash of the CB1 receptors agonist Win 55, 212-2 (5 µM, indicated as black bar). Win exposure led to a persistent and significant depression in synaptic efficacy (29.6 ± 7.49%; n = 4 slices, P = 0.024). (B) Dots represent the average amounts of LTD for each slice that make up the average (indicated as the bar). Error bars throughout represent the standard error of the mean.