Figure 2.

Morris water maze spatial learning and memory in WT and Ube3a mice given four consecutive daily training trials and treated with either vehicle or with the TrkB receptor agonist 7,8-dihydroxyflavanone (7,8-DHF, 5 mg/kg i.p.). (A) WT in both the vehicle and 7,8-DHF groups successfully reached the acquisition criterion of under 15 sec to reach the hidden platform location. No significant difference was detected in the time course for acquisition across training days between WT mice treated with vehicle versus 7,8-DHF. (B) Ube3a in both the vehicle and 7,8-DHF groups did not successfully reach the acquisition criterion of under 15 sec to reach the hidden platform location, although improvement across training days was apparent in both groups. No significant difference was detected in the time course across training days for acquisition between Ube3a mice treated with vehicle versus 7,8-DHF.