Figure 4.

Speed of swimming during Morris water maze spatial learning in WT and Ube3a mice given four consecutive daily training trials (A,B), or four daily training trials spaced by 1 h intervals (C,D), and treated with either vehicle or the TrkB receptor agonist 7,8-dihydroxyflavanone (7,8-DHF, 5 mg/kg i.p.). Ube3a swam more slowly than WT overall in both training conditions (P < 0.001). (A) The velocity of swimming did not differ between WT mice treated with vehicle versus 7,8-DHF. A significant effect of the training day was detected in WT (P < 0.001), indicating slightly faster swimming during the latter training days. No significant interaction between vehicle versus 7,8-DHF × training day was detected in WT. (B) The velocity of swimming did not differ between Ube3a mice treated with vehicle versus 7,8-DHF. A significant effect of the training day was detected (P < 0.001), indicating somewhat faster swimming across training days. No significant interaction between vehicle versus 7,8-DHF × training day was detected in Ube3a. (C) The velocity of swimming did not differ between WT mice given spaced training trials and treated with vehicle versus 7,8-DHF. No effect of the training day was detected in WT. A significant interaction between vehicle versus 7,8-DHF × training day was detected in WT (P < 0.001). (D) The velocity of swimming did not differ between Ube3a mice given spaced training trials and treated with vehicle versus 7,8-DHF. No significant effect of the training day was detected in Ube3a. No significant interaction between vehicle versus 7,8-DHF × training day was detected in Ube3a.