Figure 1.

Dose allocation and toxicity representation for the historical data. On the x-axis, the number given to the accrued patient is shown, while on the y-axis, it is marked at which dose s/he was allocated. A circle denotes that the patient did not experience any DLT, while a cross indicates that the patient had at least a DLT. The historical trial followed a CRM design with six doses, $d_i,i=1,\dots ,6$, and generating probabilities of toxicity at each dose equals to $p_T(d_1)=0.05,p_T(d_2)=0.07,p_T(d_3)=0.2,p_T(d_4)=0.4,p_T(d_5)=0.5$ and $p_T(d_6)=0.55$. This specific trial was chosen since the estimated probabilities of toxicities were similar to the generating ones.