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. 2020 Apr 23;3(4):655–665. doi: 10.1021/acsptsci.0c00015

Figure 2.

Figure 2

Spatial distribution of TFV, FTC, EFV, and RPV in mouse liver. Distribution profiles of PC (16:0/OH), TFV, FTC, EFV, and EFV–OH in liver sections of (A) female and (C) male mice following in vivo oral dosing of TFV–FTC–EFV. H&E stain indicating anatomy and orientation of liver tissue. Distribution profiles of PC (16:0/OH), TFV, FTC, RPV, and RPV–OH in liver sections obtained from (B) female and (D) male mice following in vivo oral dosing of TFV–FTC–RPV. Mice were administered drugs via their drinking water for 28 days and then sacrificed. MALDI MS ion images were generated at a spatial resolution of 50 μm. The green color represents the highest signal intensity (100%), whereas the black color depicts the lowest signal (0%) of the ion of interest. Scale bar, 1 mm.