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. Author manuscript; available in PMC: 2021 Mar 17.
Published in final edited form as: J Am Coll Cardiol. 2020 Mar 17;75(10):1239–1241. doi: 10.1016/j.jacc.2020.01.013

Figure 1: Left ventricular ejection fraction and incident cardiovascular disease in TTNtv carriers versus noncarriers.

Figure 1:

(A) Shown is the distribution of left ventricular ejection fraction and prevalence of subnormal ejection fraction among 54 TTNtv carriers and 12,499 noncarriers. In a logistic regression model adjusted for the cubic spline of age, sex, and genetic ancestry, TTNtv carriers had 12.7-fold (95%CI 6.2 – 25.8; p< 0.001) increased risk of a subnormal ejection fraction. (B) Shown are the incidence rates per 1,000 person-years for the composite endpoint and each of its components. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using a Cox regression model adjusted for the cubic spline of age, sex, and genetic ancestry.