Fig. 7. Chemical structures of small molecule inhibitors of protein kinase R-like endoplasmic reticulum kinase under investigation for their efficacy against pancreatic cancer: GSK2656157 (49), 3-(2,5-dimethoxyphenyl)-N-((4-(5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl)pyridin-2-yl) carbamoyl)-propanamide (50), SCH727965 (51), and AZD6738 (52).