Figure 5.

Exosomal miR‐204‐5p inhibits CRC growth in vivo. A, The schematic outline of the experimental design for the exosomal miR‐204‐5p treatments in mouse. HCT116 (2 × 10⁶) cells were injected subcutaneously into the right flank of each nude mouse. A week later, the volumes of tumors were about 60 mm³. GFP EXO or miR‐204 EXO was respectively injected into the xenograft tumors once every three days. These mice were sacrificed 3 days after the fifth injection. The volume and weight of mice treated with exosomal miR‐204‐5p were reduced compared with the control group. B, The effect of exosomal miR‐204‐5p therapy on the tumor growth in a nude mouse xenograft model. C, RAB22A and Bcl2 protein levels were downregulated in xenograft tissues treated with miR‐204 EXO compared with the control. *P < .05, **P < .01, ***P < .001