TABLE 1.

Identifications of proteins that were significantly different between whole‐cell lysates of 100 µM P4 versus control and 300 µM P4 vs control in A172 cell line

Spot ID	UniProt ID	Gene	Protein name	Status
9401	P04075	ALDOA	Fructose‐bisphosphate aldolase A	Upregulated in 100 µM P4
9306	P21796	VDAC1	Voltage‐dependent anion‐selective channel protein 1
1201	P61981	1433G	14‐3‐3 protein gamma	Downreguated in 100 µM P4
1201	P63104	1433Z	14‐3‐3 protein zeta/delta
1505	P08670	VIME	Vimentin
4901	P55072	TERA	Transitional endoplasmic reticulum ATPase
8705	P04040	CATA	Catalase
8705	P14618	KPYM	Pyruvate kinase PKM
9501	P68104	EF1A1	Elongation factor 1‐alpha 1
6709	P49368	TCPG	T‐complex protein 1 subunit gamma
6802	P02545	LMNA	Prelamin‐A/C
7406	P61163	ACTZ	Alpha‐centractin
7406	P49411	EFTU	Elongation factor Tu, mitochondrial
1403	P0DN37	PAL4G	Peptidyl‐prolyl cis‐trans isomerase A‐like 4G	Upregulated in 300 µM P4
1605	P26440	IVD	Isovaleryl‐CoA dehydrogenase
3704	P10809	CH60	60 kDa heat shock protein, mitochondrial
5107	P09211	GSTP1	Glutathione S‐transferase P
5107	P28070	PSB4	Proteasome subunit beta type‐4
3604	Q8NHM5	KDM2B	Lysine‐specific demethylase 2B	Downregulated in 300 µM P4
3803	P11021	BIP	Endoplasmic reticulum chaperone BiP
2506	P06576	ATPB	ATP synthase subunit beta, mitochondrial	Upregulated in both 100 µM P4 and 300 µM P4
2506	Q15084	PDIA6	Protein disulfide‐isomerase A6
8506	P06733	ENOA	Alpha‐enolase
4808	P11142	HSP7C	Heat shock cognate 71 kDa protein
6507	P04181	OAT	Ornithine aminotransferase, mitochondrial	Downregulated in both 100 µM P4 and 300 µM P4