TABLE 2.

Identifications of proteins that were significantly different between whole‐cell lysates of 100 µM P4 vs control and 300 µM P4 vs control in U87 cell line

Spot ID	UniProt ID	Gene	Protein name	Status
4605	P52597	HNRPF	Heterogeneous nuclear ribonucleoprotein F	Upregulated in 100 µM P4
5102	P15531	NDKA	Nucleoside diphosphate kinase A
4519	Q9UJZ1	STML2	Stomatin‐like protein 2, mitochondrial
3603	Q5JTZ9	SYAM	Alanine‐tRNA ligase, mitochondrial	Downregulated in 100 µM P4
7604	P26641	EF1G	Elongation factor 1‐gamma
6802	P15311	EZRI	Ezrin
7604	Q9UQ80	PA2G4	Proliferation‐associated protein 2G4
6706	P49368	TCPG	T‐complex protein 1 subunit gamma
8604	P06733	ENOA	Alpha‐enolase	Upregulated in 300 µM P4 Upregulated in 300 µM P4
4305	P12429	ANXA3	Annexin A3
3304	P08758	ANXA5	Annexin A5
9403	P00505	AATM	Aspartate aminotransferase, mitochondrial
9601	P25705	ATPA	ATP synthase subunit alpha, mitochondrial
2601	P06576	ATPB	ATP synthase subunit beta, mitochondrial
3301	O00299	CLIC1	Chloride intracellular channel protein 1
2108	Q13185	CBX3	Chromobox protein homolog 3
9501	O75390	CISY	Citrate synthase, mitochondrial
6203	P30040	ERP29	Endoplasmic reticulum resident protein 29
8604	P07954	FUMH	Fumarate hydratase, mitochondrial
9402	P04406	G3P	Glyceraldehyde‐3‐phosphate dehydrogenase
8202	P62826	RAN	GTP‐binding nuclear protein Ran
4803	P11142	HSP7C	Heat shock cognate 71 kDa protein
2403	P07910	HNRPC	Heterogeneous nuclear ribonucleoprotein C1/C2
5607	P31943	HNRH1	Heterogeneous nuclear ribonucleoprotein H
8705	P14866	HNRPL	Heterogeneous nuclear ribonucleoprotein L
9303	Q32P51	RA1L2	Heterogeneous nuclear ribonucleoprotein A1‐like 2
8502	P26440	IVD	Isovaleryl‐CoA dehydrogenase, mitochondrial
4802	Q03252	LMNB2	Lamin‐B2
6701	Q10713	MPPA	Mitochondrial‐processing peptidase subunit alpha
4202	O75489	NDUS3	NADH dehydrogenase
1305	P12004	PCNA	Proliferating cell nuclear antigen
6617	P50395	GDIB	Rab GDP dissociation inhibitor beta
1210	Q96T23	RSF1	Remodeling and spacing factor 1
6606	Q9Y265	RUVB1	RuvB‐like 1
4802	Q9Y4G6	TLN2	Talin‐2
3606	Q8NBS9	TXND5	Thioredoxin domain‐containing protein 5
1304	P06753	TPM3	Tropomyosin alpha‐3 chain
801	P27797	CALR	Calreticulin	Downregulated in 300 µM P4
4703	P30101	PDIA3	Protein disulfide‐isomerase A3
8707	P47895	AL1A3	Aldehyde dehydrogenase family 1 member A3	Upregulated in both 100 µM P4 and 300 µM P4
5202	P30084	ECHM	Enoyl‐CoA hydratase, mitochondrial
2003	P09382	LEG1	Galectin‐1
4103	P09211	GSTP1	Glutathione S‐transferase P
1409	P06748	NPM	Nucleophosmin
8002	P62937	PPIA	Peptidyl‐prolyl cis‐trans isomerase A
6208	P30041	PRDX6	Peroxiredoxin‐6
4817	P38646	GRP75	Stress‐70 protein, mitochondrial
5105	P30048	PRDX3	Thioredoxin‐dependent peroxide reductase, mitochondrial
3703	P10809	CH60	60 kDa heat shock protein, mitochondrial	Downregulated in both 100 µM P4 and 300 µM P4