TABLE 4.

Top Reactome pathways in U87 cell line with 300 µM P4 administration

Pathway	Upregulated	Downregulated
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	HSPA5	CALR, PDIA3
ATF6 (ATF6‐alpha) activates chaperone genes	HSPA5	CALR
Cellular responses to stress	GSTP1, PRDX3, PRDX6, HSPA5, HSPA8, HSPA9
Detoxification of Reactive Oxygen Species (subpathway of Cellular responses to stress)	GSTP1, PRDX3, PRDX6
Cellular response to heat stress (subpathway of Cellular responses to stress)	HSPA5, HSPA8, HSPA9
Chromosome Maintenance	NPM1, PCNA, RSF1, RUVBL1
Nucleosome assembly (subpathway of Chromosome Maintenance)	NPM1, RSF1, RUVBL1
Citric acid cycle (TCA cycle)	CS, FH
Glucose metabolism	ENO1, GAPDH, GOT2
Mitochondrial protein import	CS, ATP5F1B, HSPA9, ATP5F1A, PMPCA	HSPD1
mRNA Splicing—Major Pathway	HNRNPC, HNRNPH1, HNRNPL, HSPA8
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	NPM1	HSPD1
TP53 Regulates Transcription of Cell Cycle Genes	NPM1, PCNA
Unfolded Protein Response (UPR)	HSPA5	CALR