TABLE 5.
Top Reactome pathways in A172 cell line with 100 µM P4 administration
| Pathway | Upregulated | Downregulated |
|---|---|---|
| Apoptosis | LMNA, VIM, YWHAG, YWHAZ | |
| Cellular responses to stress | HSPA8 | ACTR1A, CAT, EEF1A1, VCP |
| Cellular response to heat stress (subpathway of Cellular responses to stress) | HSPA8 | EEF1A1, VCP |
| Chk1/Chk2(Cds1)‐mediated inactivation of Cyclin B:Cdk1 complex | YWHAG, YWHAZ | |
| Glucose metabolism | ALDOA, ENO1, GAPDH | PKM |
| Protein methylation | HSPA8 | EEF1A1, VCP |
| Regulation of mRNA stability by proteins that bind AU‐rich elements | HSPA8 | YWHAZ |
| TP53 Regulates Metabolic Genes | YWHAG, YWHAZ |