TABLE 5B.
Incidence of postoperative adjuvant chemotherapy adverse events in group B and group C ( ± s)
|
Group B (%) N = 223 |
Group C (%) N = 236 |
χ 2 | P | |||||
|---|---|---|---|---|---|---|---|---|
| 1～2 | 3～4 | 1～2 | 3～4 | 1～2 | 3～4 | 1～2 | 3～4 | |
| Hematological | ||||||||
| Leukopenia | 95 (42.60) | 10 (4.48) | 68 (28.81) | 7 (2.96) | 9.517 | 0.741 | .002 | .389 |
| Neutropenia | 59 (26.46) | 31 (13.90) | 54 (22.88) | 14 (5.93) | 0.790 | 8.235 | .374 | .004 |
| Anemia | 109 (48.88) | 18 (8.07) | 134 (56.77) | 29 (12.29) | 2.709 | 2.218 | .100 | .136 |
| Thrombocytopenia | 101 (45.29) | 5 (2.24) | 93 (39.40) | 8 (3.39) | 1.627 | 0.549 | .202 | .459 |
| AST or ALT abnormality | 123 (55.16) | 18 (8.07) | 105 (44.49) | 10 (4.24) | 5.217 | 2.943 | .014 | .086 |
| Total bilirubin increase | 103 (46.19) | 17 (7.62) | 76 (32.20) | 12 (5.08) | 9.426 | 1.248 | .002 | .264 |
| Creatinine elevation | 108 (48.43) | 10 (4.48) | 98 (41.52) | 11 (4.66) | 2.210 | 0.008 | .137 | .928 |
| Nonhematological | ||||||||
| Nausea | 106 (47.53) | 10 (4.48) | 127 (53.81) | 30 (12.71) | 2.217 | 9.752 | .136 | .002 |
| Vomiting | 73 (32.74) | 10 (4.48) | 62 (26.27) | 20 (8.47) | 2.308 | 2.989 | .129 | .084 |
| Constipation | 66 (29.60) | 10 (4.48) | 35 (14.83) | 7 (2.97) | 14.566 | 0.741 | <.001 | .389 |
| Hand‐foot syndrome | 91 (40.80) | 17 (7.62) | 98 (41.53) | 46 (19.49) | 0.024 | 13.638 | .876 | <.001 |