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AP doublet firing at depolarized membrane potentials is not T-type channel mediated. A, AP doublet firing at depolarized membrane potentials could be enhanced by low-level ramp depolarization. B, Hyperpolarization caused a transition to tonic firing in depolarized AP doublet firing neurons, which returned to AP doublet firing on subsequent spontaneous depolarization. C, Depolarized AP doublet firing was not blocked by perfusion of Z944.
