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. Author manuscript; available in PMC: 2020 Aug 18.
Published in final edited form as: Trends Analyt Chem. 2019 May 17;117:13–26. doi: 10.1016/j.trac.2019.05.010

Fig. 1.

Fig. 1.

(A) Schematic diagram of SU-8 involved soft-lithography for PDMS-based microfluidic chip fabrication. Adapted with permission from Ref. [62]. Copyright 2014 Elsevier. (B) Schematic diagram of a paper-based HaloChip fabrication and the method of the single cell HaloChip assay. (a) The steps used to form single cell arrays on ink-covered paper using microcontact printing technique; (b) The method used to assess DNA damage on the ink-covered paper using HaloChip assay. (c) Original halo image; (d) Grayscale image; (e) Identifying halos and nuclei in an array. Adapted with permission from Ref. [58]. Copyright 2016 Springer.