Fig. 4.

Dynamic cross-correlation diagrams of the fluctuations of Cα–atoms of SARS-CoV-2 PR protein in the complex of (a) hesperidin-, (b) lopinavir-bound systems, and (c) bare SARS-CoV-2 PR protein. Positive and negative values are represented in range of color red to royal blue, respectively. The diagonal square relates to the correlation of a residue with itself, i.e., only a region remarked to have highly-positive values (red). The binding regions of the SARS-CoV-2 PR protein (at residues number of 21–50 and 141–190) are demarcated with dashed lines. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)