Table 2.
Exact logistic regression analysis of candidate predictors for hypoxia requiring supplemental oxygen
|
Univariable model |
Multivariable model* |
|||
|---|---|---|---|---|
| OR (95% CI) | p value | Adjusted OR (95% CI) | p value | |
| Age, years | ||||
| <45 | 1 (ref) | ·· | 1 (ref) | ·· |
| 45–64 | 5·77 (1·84–21·73) | 0·0012 | 3·65 (1·04–14·79) | 0·042 |
| ≥65 | 13·95 (2·59–85·09) | 0·0012 | 8·05 (1·16–62·62) | 0·033 |
| Sex | ||||
| Female | 1 (ref) | ·· | ·· | ·· |
| Male | 1·51 (0·58–4·17) | 0·49 | ·· | ·· |
| Charlson Comorbidity Index | ||||
| 0 | 1 (ref) | ·· | 1 (ref) | ·· |
| ≥1 | 7·88 (2·67–24·31) | 0·0001 | 6·36 (1·76–25·68) | 0·0030 |
| Infection | ||||
| Wild-type only | 1 (ref) | ·· | 1 (ref) | ·· |
| Δ382 variant only | 0·07† (0·00–0·40) | 0·0008 | 0·07† (0·00–0·48) | 0·0035 |
| Mixed Δ382 and wild-type | 1·15 (0·18–5·53) | 1·00 | 1·78 (0·22–11·02) | 0·75 |
Δ382=382-nucleotide deletion. OR=odds ratio.
*
Adjusted for age, Charlson Comorbidity Index, and infection group.
†
As the conditional maximum likelihood estimate is unbounded (ie, infinite), the median unbiased estimate (ie, regression estimate that places the observed sufficient statistic at the median of the conditional distribution) is computed.